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indoles derivatives are widely found in large amounts of synthesis and natural productions. considering the vast structural diversity and extensive biological activities in indoles, they can be used in pharmaceutical chemistry.
in this step, Imines are produced by combination of simple Aldehydes such as formaldehydes and amino acids (cooh group), then the produced imines will be combined with indoles through a process. being single stage is the big advantage of this method which is realy beneficial in terms of cost, health, consumption of harmful solvents and reduction in reaction time. it is hoped to optimize situation in a away that productions with high efficiency can be synthesize
type of research method
in this project; the amino acids are used in different ways. firstly the cooh group-amino acid will be covered by methanol and thionyl chloride, secondly the triploid mixture of indole, amino acid and formaldehyde will react together which the electrophilic reaction is expected in this sector by considering indole resonance and activity of c-3, consequently the imine group substitution will be executed in this sector
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