T-regulatory cell modulation: the future of cancer immunotherapy?

T-regulatory cells suppress anti-tumour immunity in cancer patients and in murine tumour models. Furthermore, their activity is likely to have an effect on the effectiveness of immunotherapeutic treatments for cancer. Here we describe the current status of developing clinical strategies for modulating Treg activity in cancer patients.

Keywords: T-regulatory, tregs, immunotherapy

A strong relationship exists between T-regulatory cells (Tregs) and the development and progression of cancer. Tregs within the tumour, ascites and peripheral blood of patients with cancer are associated with poor prognosis. Increasingly, evidence suggests that Tregs protect tumours from the potentially effective immune responses. Thus, new anti-cancer strategies involving interference in Treg biology or depletion of Tregs are of critical importance. Among the plethora of agents known to affect Tregs, there are some conventional therapeutic agents. Here we describe the current status of clinical modalities, both specifically designed to target Tregs and those drugs for which their immunomodulatory function may constitute a hitherto undefined mode of action.

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http://rapidshare.com/files/241784340/6605040a.pdf.html

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